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C50.922 ICD-10-CM Code: Malignant neoplasm of unspecified site of left male breast

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FY 2026 Apr update / Neoplasms (C00-D49) / Malignant neoplasms of breast (C50)

C50.922

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Malignant neoplasm of unspecified site of left male breast

This code describes cancer that has developed in the left breast of a male patient, but the specific location within the breast tissue has not been documented. Male breast cancer is rare but requires the same treatment and monitoring as female breast cancer.

Buddy the Bee presenting code insight

Buddy Insight

Malignant neoplasm of unspecified site of left male breast captures a left-sided breast cancer in a male patient.

CMS-HCC V28

0

0

RAF 0

CMS-HCC V24

HCC 12

RAF 0.150

ACA/HHS

0

0

RAF 0

ESRD/PACE

HCC 12

RAF 0.0

RXHCC

HCC 22

RAF 0.0

Code Trumping

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Code Book Path

Official
C50.9Malignant neoplasm of breast of unspecified site
C50.92Malignant neoplasm of breast of unspecified site, male
C50.922Malignant neoplasm of unspecified site of left male breast

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for C50.922 in this effective period.

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for C50.922 in this effective period.

Related Child Codes

Official
C50.921Malignant neoplasm of unspecified site of right male breast
C50.929Malignant neoplasm of unspecified site of unspecified male breast

Includes

Official

ICD-10-CM does not list Includes notes for C50.922 in this effective period.

Excludes 1

Official

ICD-10-CM does not list Excludes 1 notes for C50.922 in this effective period.

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for C50.922 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for C50.922 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for C50.922 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance
Confirmed male patient sex
Laterality documented as left breast
Histological type (invasive ductal carcinoma most common)
TNM staging and grade

MEAT Support

HCC Buddy guidance
Confirmed male patient sex
Laterality documented as left breast
Histological type (invasive ductal carcinoma most common)
TNM staging and grade

Audit Caution

HCC Buddy guidance
Confusing male (x2x) and female (x1x) breast cancer code variants
Not querying for specific quadrant or subsite when available in imaging reports
Using this active cancer code when the patient has completed treatment and is in remission
Failing to code concurrent genetic susceptibility (Z15.01) when BRCA mutation is documented

Common Mistakes

HCC Buddy guidance
C50.912 — Unspecified site of left female breast; gender code confusion
C50.921 — Unspecified site of right male breast; laterality error
C50.929 — Unspecified site of unspecified male breast; less specific when laterality is known

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

Is C50.922 an HCC code?

Yes. C50.922 maps to Breast, Prostate, and Other Cancers and Tumors under the V24 model but is not retained in V28.

HCC Category Mapping

V24HCC 12, Breast, Prostate, and Other Cancers and Tumors
0.150
ESRDHCC 12, Breast, Prostate, and Other Cancers and Tumors
0.000
RxHCCHCC 22, Cancer, Other Specified Sites
0.000

RAF weights shown are the community, non-dual, aged base weights from the CMS risk adjustment model file. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.

MEAT Criteria for C50.922

For C50.922to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.

  • MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
  • EEvaluate: test results, medication response, or physical findings reviewed by the provider
  • AAssess: explicit mention in the assessment or plan with acknowledgment of status
  • TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed C50.922 during that encounter, not just copy-forwarded from a problem list.

What This Code Means

C50.922 is the ICD-10-CM diagnosis code for malignant neoplasm of unspecified site of left male breast. This code describes cancer that has developed in the left breast of a male patient, but the specific location within the breast tissue has not been documented. Male breast cancer is rare but requires the same treatment and monitoring as female breast cancer. C50.922 sits in the ICD-10-CM chapter for neoplasms (c00-d49), within the section covering malignant neoplasms of breast (c50).

Under the older CMS-HCC V24 model, C50.922 maps to Breast, Prostate, and Other Cancers and Tumors (HCC 12) with a community, non-dual, aged base RAF weight of 0.150. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.

Verify documentation specifies the cancer is in the left breast and that the site is truly unspecified; if a specific quadrant or location is documented, use a more specific C50.9 code variant. Because C50.922 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for C50.922 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

  • Verify documentation specifies the cancer is in the left breast and that the site is truly unspecified; if a specific quadrant or location is documented, use a more specific C50.9 code variant
  • Ensure this code is used only for male patients; female breast cancer uses different C50 codes (C50.1-C50.9 with different laterality indicators)

Clinical Significance

Malignant neoplasm of unspecified site of left male breast captures a left-sided breast cancer in a male patient. Male breast cancer has distinct epidemiological features including association with BRCA2 mutations, Klinefelter syndrome, and radiation exposure. Left-sided predominance has been observed in some studies, making laterality documentation clinically relevant.

Documentation Requirements

  • Confirmed male patient sex
  • Laterality documented as left breast
  • Histological type (invasive ductal carcinoma most common)
  • TNM staging and grade
  • Receptor status documentation
  • Genetic testing results (BRCA1/BRCA2) when performed
  • Treatment plan and disease status

Commonly Confused Codes

  • C50.912 — Unspecified site of left female breast; gender code confusion
  • C50.921 — Unspecified site of right male breast; laterality error
  • C50.929 — Unspecified site of unspecified male breast; less specific when laterality is known

Child Codes

Code Hierarchy

More on C50.922

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